Distances and Isomorphism between Networks and the Stability of Network Invariants

We develop the theoretical foundations of a network distance that has recently been applied to various subfields of topological data analysis, namely persistent homology and hierarchical clustering. While this network distance has previously appeared in the context of finite networks, we extend the setting to that of compact networks. The main challenge in this new setting is the lack of an easy notion of sampling from compact networks; we solve this problem in the process of obtaining our results. The generality of our setting means that we automatically establish results for exotic objects such as directed metric spaces and Finsler manifolds. We identify readily computable network invariants and establish their quantitative stability under this network distance. We also discuss the computational complexity involved in precisely computing this distance, and develop easily-computable lower bounds by using the identified invariants. By constructing a wide range of explicit examples, we show that these lower bounds are effective in distinguishing between networks. Finally, we provide a simple algorithm that computes a lower bound on the distance between two networks in polynomial time and illustrate our metric and invariant constructions on a database of random networks and a database of simulated hippocampal networks

The Importance of Forgetting: Limiting Memory Improves Recovery of Topological Characteristics from Neural Data

We develop of a line of work initiated by Curto and Itskov towards understanding the amount of information contained in the spike trains of hippocampal place cells via topology considerations. Previously, it was established that simply knowing which groups of place cells fire together in an animal's hippocampus is sufficient to extract the global topology of the animal's physical environment. We model a system where collections of place cells group and ungroup according to short-term plasticity rules. In particular, we obtain the surprising result that in experiments with spurious firing, the accuracy of the extracted topological information decreases with the persistence (beyond a certain regime) of the cell groups. This suggests that synaptic transience, or forgetting, is a mechanism by which the brain counteracts the effects of spurious place cell activity

The Metric Space of Networks

We study the question of reconstructing a weighted, directed network up to isomorphism from its motifs. In order to tackle this question we first relax the usual (strong) notion of graph isomorphism to obtain a relaxation that we call weak isomorphism. Then we identify a definition of distance on the space of all networks that is compatible with weak isomorphism. This global approach comes equipped with notions such as completeness, compactness, curves, and geodesics, which we explore throughout this paper. Furthermore, it admits global-to-local inference in the following sense: we prove that two networks are weakly isomorphic if and only if all their motif sets are identical, thus answering the network reconstruction question. Further exploiting the additional structure imposed by our network distance, we prove that two networks are weakly isomorphic if and only if certain essential associated structures---the skeleta of the respective networks---are strongly isomorphic